Displaying 1 of 1 2023 Format: Book Author: Patrick, Graham L., author. Title: An introduction to medicinal chemistry / Graham L. Patrick. Edition: Seventh edition. Publisher, Date: New York, NY : Oxford University Press, [2023] Description: xxx, 925 pages : illustrations (some color) ; 28 cm Summary: Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug. Subjects: Pharmaceutical chemistry. Chemistry, Pharmaceutical Pharmaceutical chemistry Notes: Revised edition of: An introduction to medicinal chemistry / Graham L. Patrick. Sixth edition. 2017. "Fourth edition 2009, Fifth edition 2013, Sixth edition 2017"-- copyright page. Includes bibliographical references and index. Contents: 1. Drugs and drug targets: an overview -- Part A. Drug targets: structure and function. 2. Protein structure and function -- 3. Enzymes: structure and function -- 4. Receptors: structure and function -- 5. Receptors and signal transaction -- 6. Nucleic acids: structure and function -- Part B. Pharmacodynamics and pharmacokinetics. 7. Enzymes as drug targets -- 8. Receptors as drug targets -- 9. Nucleic acids as drug targets -- 10. Miscellaneous drug targets -- 11. Pharmacokinetics and related topics -- Case study 1 Statins -- Part C. Drug discovery, design, and development. 12. Drug discovery: finding a lead -- 13. Drug design: optimizing target interactions -- 14. Drug design: optimizing access to the target -- 15. Getting the drug to market -- Case study 2 The design of ACE inhibitors -- Case study 3 Artemisinin and related antimalarial drugs -- Case study 4 The design of oxamniquine -- Case study 5 Fosmidomycin as an antimalarial agent -- Part D. Tools of the trade. 16. Combinatorial and parallel synthesis -- 17. In silico drug design -- 18. Quantitative structure-activity relationships (QSAR) -- Case study 6 Design of a thymidylate synthase inhibitor -- Part E. Selected topics in medicinal chemistry. 19. Antibacterial agents -- 20. Antiviral agents -- 21. Anticancer agents -- 22. Protein kinase inhibitors as anticancer agents -- 23. Antibodies and other biologics -- 24. Cholinergics, anticholinergics, and anticholinesterases -- 25. Drugs acting on the adrenergic nervous system -- 26. The opioid analgesics -- 27. Anti-ulcer agents -- 28. Cardiovascular drugs -- Case study 7 Steroidal anti-inflammatory agents -- Case study 8 Current research into antidepressant agents -- Case study 9 The design and development of aliskiren -- Case study 10 Factor Xa inhibitors -- Case study 11 Reversible inhibitors of HCV NS3-4A protease -- Appendix 1. Essential amino acids -- Appendix 2. The standard genetic code -- Appendix 3. Statistical data for QSAR -- Appendix 4. The action of nerves -- Appendix 5. Microorganisms -- Appendix 6. Drugs and their trade names -- Appendix 7. Trade name (drug name) -- Appendix 8. Potential hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs) in common functional groups -- Appendix 9. Using the Protein Data Bank. LCCN: 2022944304 ISBN: 9780198866664 0198866666 9780198869436 0198869436 * 9780192636478 Other Number: 1368268738 System Availability: 1 Current Holds: 0 # Local items: 1 Control Number: 536238 Call Number: RS403 .P38 2023 Course Reserves: 0 # Local items in: 0 # System items in: 0 Expand All | Collapse All Availability Displaying 1 of 1